MaghrebDataLibMedV2, Main, Exploration, bibRecord, 000501

Immunodominant IgE Epitopes of Der p 5 Allergen.

Identifieur interne : 000501 ( Main/Exploration ); précédent : 000500; suivant : 000502

Immunodominant IgE Epitopes of Der p 5 Allergen.

Auteurs : Sadjia Lahiani [Algérie, Belgique] ; Marie-Eve Dumez [Belgique] ; Ahlem Bouaziz [Belgique] ; Kamel Djenouhat [Algérie] ; Souad Khemili [Algérie, Belgique] ; Idir Bitam [Algérie] ; Dimitri Gilis [Belgique] ; Moreno Galleni [Belgique]

Source :

Protein and peptide letters [ 1875-5305 ] ; 2018.

RBID : pubmed:30430936

Descripteurs français

English descriptors

KwdEn :
- Amino Acid Sequence (MeSH), Amino Acid Substitution (MeSH), Antigens, Dermatophagoides (chemistry), Antigens, Dermatophagoides (immunology), Arthropod Proteins (chemistry), Arthropod Proteins (immunology), Humans (MeSH), Immunodominant Epitopes (chemistry), Immunodominant Epitopes (genetics), Immunodominant Epitopes (immunology), Immunoglobulin E (immunology), Models, Molecular (MeSH), Protein Conformation (MeSH), Sequence Alignment (MeSH).
MESH :
- chemical , chemistry : Antigens, Dermatophagoides, Arthropod Proteins, Immunodominant Epitopes.
- chemical , genetics : Immunodominant Epitopes.
- chemical , immunology : Antigens, Dermatophagoides, Arthropod Proteins, Immunodominant Epitopes, Immunoglobulin E.
- Amino Acid Sequence, Amino Acid Substitution, Humans, Models, Molecular, Protein Conformation, Sequence Alignment.

Abstract

BACKGROUND

Der p 5 is an important allergen of Dermatophagoides pteronyssinus that plays a key role in allergic airway diseases. Its three dimensional structure (PDB 3MQ1) consists of three anti-parallel α-helices arranged in a helical bundle. Aggregation of Der p5 can modulate its allergenicity. This study aimed to identify the key residues of IgE binding epitopes of Der p 5.

METHODS

IgE binding epitopes of Der p 5 were characterized as follow. An in silico prediction of the epitope was performed with the help of SEPPA program. We also made a mapping of the epitope by using an overlapping library of peptides that encompass the sequence of mature Der p 5. Finally, an alanine scanning mutagenesis allowed us to define the key residues of the allergen involved in its interaction with IgE. The integrity of the structure of the different protein's mutants was assessed by far UV circular dichroism.

RESULTS

The presented data indicate that the major epitope sequence of Der p 5 is 90DRLMQRKDLDIFEQYNLEM108. Residues L98, D99, I100, F101, E102 and Y104 appear to be important for IgE binding.

CONCLUSION

This study highlighted the residues of Der p 5 essential for IgE binding. The identification of the major residues epitope of Der p 5 allergen may participate in the selection and engineering of new hypoallergens used in immunotherapy.

DOI: 10.2174/0929866525666181114144635
PubMed: 30430936

Affiliations:

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence (MeSH)</term>
<term>Amino Acid Substitution (MeSH)</term>
<term>Antigens, Dermatophagoides (chemistry)</term>
<term>Antigens, Dermatophagoides (immunology)</term>
<term>Arthropod Proteins (chemistry)</term>
<term>Arthropod Proteins (immunology)</term>
<term>Humans (MeSH)</term>
<term>Immunodominant Epitopes (chemistry)</term>
<term>Immunodominant Epitopes (genetics)</term>
<term>Immunodominant Epitopes (immunology)</term>
<term>Immunoglobulin E (immunology)</term>
<term>Models, Molecular (MeSH)</term>
<term>Protein Conformation (MeSH)</term>
<term>Sequence Alignment (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences (MeSH)</term>
<term>Antigènes de Dermatophagoides (composition chimique)</term>
<term>Antigènes de Dermatophagoides (immunologie)</term>
<term>Conformation des protéines (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Immunoglobuline E (immunologie)</term>
<term>Modèles moléculaires (MeSH)</term>
<term>Protéines d'arthropode (composition chimique)</term>
<term>Protéines d'arthropode (immunologie)</term>
<term>Substitution d'acide aminé (MeSH)</term>
<term>Séquence d'acides aminés (MeSH)</term>
<term>Épitopes immunodominants (composition chimique)</term>
<term>Épitopes immunodominants (génétique)</term>
<term>Épitopes immunodominants (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antigens, Dermatophagoides</term>
<term>Arthropod Proteins</term>
<term>Immunodominant Epitopes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Immunodominant Epitopes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Dermatophagoides</term>
<term>Arthropod Proteins</term>
<term>Immunodominant Epitopes</term>
<term>Immunoglobulin E</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Antigènes de Dermatophagoides</term>
<term>Protéines d'arthropode</term>
<term>Épitopes immunodominants</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Épitopes immunodominants</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes de Dermatophagoides</term>
<term>Immunoglobuline E</term>
<term>Protéines d'arthropode</term>
<term>Épitopes immunodominants</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Amino Acid Substitution</term>
<term>Humans</term>
<term>Models, Molecular</term>
<term>Protein Conformation</term>
<term>Sequence Alignment</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term>
<term>Conformation des protéines</term>
<term>Humains</term>
<term>Modèles moléculaires</term>
<term>Substitution d'acide aminé</term>
<term>Séquence d'acides aminés</term>
</keywords>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Der p 5 is an important allergen of Dermatophagoides pteronyssinus that plays a key role in allergic airway diseases. Its three dimensional structure (PDB 3MQ1) consists of three anti-parallel α-helices arranged in a helical bundle. Aggregation of Der p5 can modulate its allergenicity. This study aimed to identify the key residues of IgE binding epitopes of Der p 5.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>IgE binding epitopes of Der p 5 were characterized as follow. An in silico prediction of the epitope was performed with the help of SEPPA program. We also made a mapping of the epitope by using an overlapping library of peptides that encompass the sequence of mature Der p 5. Finally, an alanine scanning mutagenesis allowed us to define the key residues of the allergen involved in its interaction with IgE. The integrity of the structure of the different protein's mutants was assessed by far UV circular dichroism.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>The presented data indicate that the major epitope sequence of Der p 5 is 90DRLMQRKDLDIFEQYNLEM108. Residues L98, D99, I100, F101, E102 and Y104 appear to be important for IgE binding.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>This study highlighted the residues of Der p 5 essential for IgE binding. The identification of the major residues epitope of Der p 5 allergen may participate in the selection and engineering of new hypoallergens used in immunotherapy.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Algérie</li>
<li>Belgique</li>
</country>
<region><li>Province de Liège</li>
<li>Région de Bruxelles-Capitale</li>
<li>Région wallonne</li>
<li>Wilaya d'Alger</li>
</region>
<settlement><li>Alger</li>
<li>Bruxelles</li>
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<li>Université libre de Bruxelles</li>
</orgName>
</list>
<tree><country name="Algérie"><noRegion><name sortKey="Lahiani, Sadjia" sort="Lahiani, Sadjia" uniqKey="Lahiani S" first="Sadjia" last="Lahiani">Sadjia Lahiani</name>
</noRegion>
<name sortKey="Bitam, Idir" sort="Bitam, Idir" uniqKey="Bitam I" first="Idir" last="Bitam">Idir Bitam</name>
<name sortKey="Djenouhat, Kamel" sort="Djenouhat, Kamel" uniqKey="Djenouhat K" first="Kamel" last="Djenouhat">Kamel Djenouhat</name>
<name sortKey="Khemili, Souad" sort="Khemili, Souad" uniqKey="Khemili S" first="Souad" last="Khemili">Souad Khemili</name>
</country>
<country name="Belgique"><region name="Région wallonne"><name sortKey="Lahiani, Sadjia" sort="Lahiani, Sadjia" uniqKey="Lahiani S" first="Sadjia" last="Lahiani">Sadjia Lahiani</name>
</region>
<name sortKey="Bouaziz, Ahlem" sort="Bouaziz, Ahlem" uniqKey="Bouaziz A" first="Ahlem" last="Bouaziz">Ahlem Bouaziz</name>
<name sortKey="Dumez, Marie Eve" sort="Dumez, Marie Eve" uniqKey="Dumez M" first="Marie-Eve" last="Dumez">Marie-Eve Dumez</name>
<name sortKey="Galleni, Moreno" sort="Galleni, Moreno" uniqKey="Galleni M" first="Moreno" last="Galleni">Moreno Galleni</name>
<name sortKey="Gilis, Dimitri" sort="Gilis, Dimitri" uniqKey="Gilis D" first="Dimitri" last="Gilis">Dimitri Gilis</name>
<name sortKey="Khemili, Souad" sort="Khemili, Souad" uniqKey="Khemili S" first="Souad" last="Khemili">Souad Khemili</name>
</country>
</tree>
</affiliations>
</record>

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   |area=    MaghrebDataLibMedV2
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:30430936
   |texte=   Immunodominant IgE Epitopes of Der p 5 Allergen.
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	Serveur sur les données et bibliothèques médicales au Maghreb (version finale)
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Serveur sur les données et bibliothèques médicales au Maghreb (version finale)

Immunodominant IgE Epitopes of Der p 5 Allergen.

Immunodominant IgE Epitopes of Der p 5 Allergen.

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